منابع مشابه
Hodgkin lymphoma transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma.
Transformation to a large cell lymphoma may occur during the course of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) in approximately 5% of the cases. This is known as Richter's transformation. A much less frequent transformation to Hodgkin lymphoma may occur. We report a case of CLL/SLL in which a transformation to Hodgkin lymphoma occurred, and we review previously publish...
متن کاملRichter's transformation in chronic lymphocytic leukemia.
Richter's transformation, or Richter's syndrome, is an uncommon clinicopathological condition observed in about 5% to 10% of patients with chronic lymphocytic leukemia (CLL). "Richter's transformation" refers to the development of aggressive lymphoma during the course of CLL. Diffuse large B-cell lymphoma occurs in the majority of cases of Richter's transformation. Clinically, patients with Ric...
متن کاملRichter syndrome: chronic lymphocytic leukemia transformation into Hodgkin's disease.
r ichter syndrome is a clinical condition in which indolent chronic lymphocytic leukemia evolves into a more aggressive diffuse large B cell lymphoma. Maurice Nethaniel Richter first described this phenomenon in 1928, which was named the “Richter syndrome” in 1964 [1]. Due to the aggressive nature of the disorder, the clinical manifestations, prognosis and treatment differ from CLL1 [2]. Sympto...
متن کاملTransformation of chronic lymphocytic leukemia/small lymphocytic lymphoma to interdigitating dendritic cell sarcoma: evidence for transdifferentiation of the lymphoma clone.
Interdigitating dendritic cell sarcoma (IDCS) is a rare tumor derived from interdigitating dendritic cells. Three cases of IDCS associated with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) have been described, but no clonal relationship between the 2 neoplasms was demonstrated. We present a detailed case analysis of a CLL/SLL with metachronous IDCS and demonstrate that thes...
متن کاملSecondary CD5+ diffuse large B-cell lymphoma not associated with transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma (Richter syndrome).
Few cases of secondary CD5+ diffuse large B-cell lymphoma (DLBCL) that are not Richter syndrome have been reported previously. We report 9 cases of non-Richter syndrome secondary CD5+ DLBCL. Among 529 cases of DLBCL, 38 (7.2%) were CD5+ DLBCL, including 9 of secondary CD5+ DLBCL. Five cases gained CD5 expression during the clinical course of DLBCL (group 1). Three cases showed transformation fr...
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ژورنال
عنوان ژورنال: BMJ
سال: 1964
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.5422.1460-e